Polynucleotides

What Are Polynucleotides?

Polynucleotides are an advanced injectable treatment containing DNA fractions derived from highly purified salmon or trout DNA. These biocompatible molecules work at a cellular level to stimulate your skin's natural regenerative processes, promoting healing, hydration, and rejuvenation from within.

Unlike traditional dermal fillers that simply add volume, polynucleotides actively repair damaged tissue, improve skin quality, and stimulate the production of collagen and elastin. They create an optimal environment for cellular regeneration, making them one of the most innovative anti-ageing treatments available.

Dr Hajra offers this revolutionary treatment to help restore your skin's vitality, improve tone and texture, and achieve natural, long-lasting rejuvenation.

How Polynucleotides Work

Advanced regenerative science for your skin

DNA Fragments

Purified polynucleotide chains deliver bioactive molecules to stimulate cellular repair

Tissue Regeneration

Activates fibroblasts to produce new collagen and elastin naturally

Antioxidant Protection

Protects cells from free radical damage and environmental stressors

Deep Hydration

Improves skin moisture levels and enhances natural hydration mechanisms

Key Benefits

Why choose polynucleotides?

Stimulates natural tissue regeneration and repair
Boosts collagen and elastin production
Improves skin hydration and elasticity
Reduces fine lines and wrinkles
Enhances overall skin quality and radiance
Addresses dark circles and under-eye concerns
Improves skin tone and texture
Reduces inflammation and promotes healing
Natural, progressive results
Minimal downtime with long-lasting effects
Suitable for delicate and sensitive areas
Biocompatible with excellent safety profile

What to Expect

Treatment

Precise injections delivering regenerative polynucleotides to target areas

Treatment Time

30-45 minutes including preparation and consultation

Downtime

Minimal - slight redness and swelling for 24-48 hours

Results

Gradual improvement over 3-4 weeks, optimal at 6-8 weeks

Duration

6-12 months with progressive improvement

Treatment Areas

Versatile regenerative therapy for multiple concerns

Under Eyes

Reduce dark circles, hollows, and fine lines for a refreshed appearance

Full Face

Overall facial rejuvenation and skin quality improvement

Neck

Tighten and smooth neck skin, reducing crepiness and lines

Décolletage

Improve texture and firmness in the chest area

Hands

Rejuvenate ageing hands with improved skin quality

Nasolabial Folds

Soften smile lines and improve skin quality

Forehead

Smooth texture and reduce fine lines

Acne Scars

Promote healing and reduce scarring through tissue regeneration

Polynucleotides vs Other Treatments

Regenerates tissue at cellular level
Long-term skin quality improvement
Stimulates natural collagen production
Repairs and heals damaged skin
Excellent for under-eye area
Progressive, natural-looking results
Anti-inflammatory properties

Skin Boosters (HA)

Primarily provides hydration
Plumps and smooths skin
Temporary hydration boost
Does not repair tissue
Results visible quickly
Shorter duration of effect
Limited regenerative capacity

Best Used Together

Polynucleotides and traditional skin boosters can be combined for comprehensive results - polynucleotides for long-term regeneration and skin boosters for immediate hydration. Dr Hajra will recommend the best approach for your needs.

What to Expect During Treatment

1. Consultation & Assessment

Dr Hajra will conduct a thorough skin assessment to evaluate your concerns and determine if polynucleotides are the right treatment for you. She'll discuss your medical history, expectations, and create a personalised treatment plan.

2. Preparation

The treatment area will be thoroughly cleansed. A topical numbing cream is applied to ensure maximum comfort during the procedure, particularly for sensitive areas like under the eyes.

3. Injection

Using ultra-fine needles or a micro-cannula, Dr Hajra will carefully inject the polynucleotide solution into the target areas. The technique varies depending on the treatment area - under eyes require meticulous precision, while facial treatments may use multiple injection points for even distribution.

4. Post-Treatment Care

A cooling or soothing gel may be applied to minimise any immediate redness or swelling. You'll receive comprehensive aftercare instructions to optimise your results and ensure smooth recovery.

5. Follow-Up

Most patients benefit from a course of 2-3 treatments spaced 3-4 weeks apart for optimal results. Dr Hajra will schedule follow-up appointments to monitor your progress and plan any maintenance treatments.

Recommended Treatment Course

For optimal, long-lasting results, polynucleotide treatments typically require an initial course of 2-3 sessions spaced 3-4 weeks apart. This allows the regenerative processes to build progressively, creating sustainable improvements in skin quality.

Unlike temporary treatments, polynucleotides create lasting change by stimulating your body's natural repair mechanisms. The effects continue to develop even after treatment, with results lasting 6-12 months or longer.

Maintenance treatments are usually recommended every 6-12 months to sustain optimal skin health. Dr Hajra will create a bespoke treatment plan tailored to your skin's unique needs and your aesthetic goals.

Treatment Timeline

Session 1

Initial treatment to begin cellular regeneration process

Week 1-2

Early improvements in hydration and skin texture

Week 3-4

Second treatment to enhance regenerative effects

Week 6-8

Noticeable improvement in skin quality, tone, and radiance

3-6 Months

Continued improvement as collagen remodeling progresses

6-12 Months

Maintenance treatment to sustain results

Am I a Good Candidate for Polynucleotides?

Polynucleotides are suitable for most adults seeking natural, regenerative skin rejuvenation with long-lasting results.

You're a Good Candidate If You:

Have signs of ageing or skin damage
Want to improve under-eye dark circles or hollows
Have dull, tired-looking skin
Experience skin laxity or loss of elasticity
Have fine lines and wrinkles
Seek long-term skin quality improvement
Want natural, progressive results
Have scarring or uneven skin texture
Are looking for preventative anti-ageing treatment
Have sun-damaged or environmentally damaged skin
Are in good general health

Treatment May Not Be Suitable If You:

Are pregnant or breastfeeding
Have active skin infections or inflammation
Have allergies to fish or fish products
Have autoimmune disorders (discuss with Dr Hajra)
Are taking immunosuppressant medications
Have bleeding disorders or take blood thinners
Would like immediate results
Have active cold sores (if treating near mouth)

A thorough consultation with Dr Hajra will determine if polynucleotides are the right treatment for your specific needs and medical history.

Aftercare Guidelines

Following these aftercare instructions will help optimise your results and support the regenerative healing process.

Do

Keep the treated area clean and moisturised
Apply SPF 30+ daily to protect healing skin
Drink plenty of water to support healing
Sleep elevated for the first 2 nights if treating under eyes
Use gentle, non-irritating skincare products
Apply cold compresses if you experience swelling
Be patient - results develop gradually
Contact Dr Hajra with any concerns
Attend all scheduled follow-up appointments

Don't

Touch, rub, or massage the treated area for 24 hours
Apply makeup for at least 12 hours
Exercise vigorously for 48 hours
Expose skin to extreme heat (sauna, steam) for 2 weeks
Have dental work for 2 weeks
Have facial treatments or peels for 2-4 weeks
Consume excessive alcohol for 48 hours
Expose treated areas to direct sun without SPF
Use active skincare (retinol, acids) for 48 hours

Expected Side Effects

Mild side effects are normal and typically resolve within a few days:

Redness and slight swelling at injection sites (24-48 hours)
Small bumps or papules under the skin (normal, will settle)
Minor bruising, especially around delicate areas like eyes
Mild tenderness or sensitivity
Temporary firmness in treated areas

Combining Polynucleotides with Other Treatments

Polynucleotides work excellently alongside other aesthetic treatments for comprehensive facial rejuvenation.

Anti-Wrinkle Injections

Combine for wrinkle reduction and improved skin quality

Dermal Fillers

Address volume loss while regenerating skin quality

Skin Boosters

Layer hydration with tissue regeneration for optimal results

Chemical Peels

Enhance surface texture while polynucleotides work deeper

Microneedling

Boost collagen production through dual stimulation methods

Medical Skincare

Maintain and enhance results with targeted skincare

Frequently Asked Questions

Polynucleotides are chains of DNA molecules extracted and purified from salmon DNA, which is biocompatible with human tissue. When injected into the skin, they stimulate fibroblast activity, promote cellular regeneration, boost collagen and elastin production, and provide antioxidant protection. Unlike fillers that add volume, polynucleotides actually repair and regenerate your skin at a cellular level, creating lasting improvements in skin quality and health.

Yes, polynucleotides have an excellent safety profile. They are biocompatible, meaning they integrate naturally with human tissue. The DNA fragments are highly purified and have been extensively tested. However, if you have an allergy to fish or fish products, polynucleotides may not be suitable for you. Dr Hajra will discuss your medical history during consultation to ensure treatment safety.

Most patients find the treatment comfortable. A topical anaesthetic cream is applied before treatment to minimise any discomfort. You may feel slight pressure or pinpricks during injection, but pain is minimal. The under-eye area is particularly sensitive, so extra care is taken to ensure your comfort. Many patients report the treatment is more comfortable than they anticipated.

Results typically last 6-12 months or longer because polynucleotides create real biological change rather than temporary cosmetic enhancement. As the treatment stimulates your body's own collagen production and repair mechanisms, improvements continue to develop over time. With regular maintenance treatments, many patients find their results become progressively better and longer-lasting.

Initial improvements in hydration and skin texture may be visible within 1-2 weeks, but polynucleotides work progressively. Optimal results typically become apparent at 6-8 weeks as collagen remodeling occurs. Results continue to improve over the following months as your skin regenerates. This gradual improvement creates natural-looking, sustainable results rather than dramatic overnight changes.

An initial course of 2-3 treatments spaced 3-4 weeks apart is typically recommended for optimal results. This allows the regenerative effects to build progressively. After completing the initial course, maintenance treatments every 6-12 months help sustain results. Dr Hajra will create a personalised treatment plan based on your individual needs and goals.

While both are injectable treatments, they work differently. Skin boosters (like Profhilo) primarily provide intense hydration using hyaluronic acid. Polynucleotides go further by actually regenerating tissue, stimulating DNA repair, promoting collagen production, and healing damaged skin at a cellular level. Polynucleotides create longer-lasting, more comprehensive improvements in skin quality. Both can be used together for optimal results.

Downtime is minimal. You may experience redness, slight swelling, or small bumps at injection sites for 24-48 hours. Some bruising is possible, particularly around the delicate under-eye area. Most patients return to normal activities immediately, though it's advised to avoid strenuous exercise and heat exposure for 48 hours. Any visible side effects typically resolve within a few days.

Yes, polynucleotides are excellent for treating under-eye concerns. They improve skin quality, reduce dark circles, smooth fine lines, and address hollowing. By regenerating the delicate under-eye skin and improving blood circulation, polynucleotides create a more refreshed, youthful appearance. This is one of the most popular treatment areas for polynucleotides.

Absolutely. Polynucleotides work excellently alongside other aesthetic treatments such as anti-wrinkle injections, dermal fillers, skin boosters, and chemical peels. They can be part of a comprehensive treatment plan to address multiple aesthetic concerns. Dr Hajra will advise on the best combination and timing of treatments to achieve your desired results safely and effectively.

Ready to regenerate your skin?

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Experience Next-Generation Skin Regeneration

Discover the transformative power of polynucleotides. Book your consultation with Dr Hajra to learn how this revolutionary treatment can rejuvenate your skin from within.

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Polynucleotides in Belsize Park, London